| 货号 | 5340/50 |
| 别名 | 1,1'-(2,2-Dimethyl-1,3-propanediyl)b |
| 供应商 | Tocris |
| 生物活性 | Werner syndrome helicase (WRN) helicase inhibitor (IC50 = 250 nM); acts synergistically with Mitomycin C (Cat. No. 3258) to induce double-strand breaks and chromosomal abnormalities in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 400.04 |
| 分子式 | C13H10Cl4N2< |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO |
| 参考文献 | Aggarwalet al (2013) Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway. Cancer Res. 73 5497. PMID: 23867477. Aggarwalet al (2013) Targeting an Achilles' heel of cancer with a WRN helicase inhibitor. Cell Cycle 12 3329. PMID: 24036544. |