| 货号 | 3062/50 |
| 别名 | N,N'-Bis[2-hydroxy-5-(trifluoromethy |
| 供应商 | Tocris |
| 生物活性 | Human ether-a-go-go related gene (hERG) KV11.1 channel activator (EC50 = 10.5 μM). Exhibits different molecular mechanisms of action at KV11.1 (hERG1) and KV11.2 (hERG2) channels. Displays antiarrhythmic activity in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 380.24 |
| 分子式 | C15H10F6N2O3 |
| 可溶性/溶解性 | Soluble to 100 mM in ethanol and to 25 mM in DMSO |
| CAS号 | 448895-37-2 |
| 参考文献 | Elmedybet al (2007) Activation of ERG2 potassium channel by the diphenylurea NS1643. Neuropharmacology 53 283. PMID: 17610913. Casiset al (2006) Mechanism of action of a novel human ether-a-go-ao related gene channel activator. Mol.Pharmacol. 69 658. PMID: 16284303. Hansenet al (2006) Activation of human ether-a-go-go related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643). Mol.Pharmacol. 69 266. PMID: 16219910. |