| 货号 | 2777/50 |
| 别名 | 2-[3-[4-(3-Chlorophenyl)-1-piperazi |
| 供应商 | Tocris |
| 生物活性 | Serotonin 5-HT2A receptor antagonist (Ki = 5.8 nM) and inhibitor of serotonin and noradrenalin uptake (IC50 values are 290 and 300 nM respectively). Displays no activity at 5-HT1B and 5-HT1D receptors. Active in models predictive of antidepressant potential. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 506.47 |
| 分子式 | C25H32ClN5O2.HCl |
| 可溶性/溶解性 | Soluble to 10 mM in 1eq. HCl and to 25 mM in DMSO |
| CAS号 | 82752-99-6 |
| 参考文献 | Pullaret al (2000) LY367265, an inhibitor of the 5-hydroxytryptamine transporter and 5-hydroxytryptamine2A receptor antagonist: a comparison with the antidepressant, nefazodone. Eur.J.Pharmacol. 407 39. PMID: 11050288. Daviset al (1997) Nefazodone. A review of its pharmacology and clinical efficacy in the management of major depression. Drugs 53 608. PMID: 9098663. Eisonet al (1990) Nefazodone: preclinical pharmacology of a new antidepressant. Psychopharmacol.Bull. 26 311. PMID: 2274630. |