| 货号 | 0500/50 |
| 供应商 | Tocris |
| 生物活性 | Powerful antineoplastic agent in cultured cells and animal tumors (IC50 = 0.2 μM in L1210 cells). Inhibitor of polyamine synthases. Suppressor of mitochondrial DNA synthesis. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 计算分子量 | 404.29 |
| 分子式 | C14H34N4.4HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| CAS号 | 113812-15-0 |
| 参考文献 | Bergeronet al (2005) Synthesis and bioloigcal evaluation of aminopolyamines. J.Med.Chem. 48 3099. PMID: 15857111. Vertinoet al (1991) Selective cellular depletion of mitochondrial DNA by the polyamine analog N1,N12-bis(ethyl)spermine and its relationship to polyamine structure and function. Mol.Pharmacol. 39 487. PMID: 2017149. Porteret al (1990) Combined regulation of arginine and S-adenosylmethionine decarboxylases by spermine and the spermine analogue N1,N12-bis(ethyl)spermine. Biochem.J. 268 207. PMID: 2344358. Bergeronet al (1988) Synthetic polyamine analogues as antineoplastics. J.Med.Chem. 31 1183. PMID: 3373487. |