| 货号 | 2545/50 |
| 别名 | 1-(4-Chlorophenyl)-2-[[3-(10,11-dih |
| 供应商 | Tocris |
| 生物活性 | Serotonin and noradrenalin re-uptake inhibitor (SNRI) that is metabolized to desipramine. Produces inhibition of liver tryptophan pyrollase activity in vitro and displays antidepressant properties in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 418.97 |
| 分子式 | C26H27N2OCl |
| 可溶性/溶解性 | Soluble to 75 mM in DMSO and to 10 mM in ethanol |
| CAS号 | 23047-25-8 |
| 参考文献 | Kelly and Leonard (1999) An investigation of the antidepressant properties of lofepramine and its desmethylated metabolites in the forced swim and olfactory bulbectomized rat models of depression. Eur.Neuropsychopharmacol. 9 101. PMID: 10082234. Badawyet al (1991) The effects of lofepramine and desmethylimipramine on tryptophan metabolism and disposition in the rat Biochem.Pharmacol. 42 921. PMID: 1867646. Leonard (1987) A comparison of the pharmacological properties of the novel tricyclic antidepressant lofepramine with its major metabolite, desipramine: a review. Int.Clin.Psychopharmacol. 2 281. PMID: 2891742. |