| 货号 | 3998/50 |
| 别名 | 5-Chloro-1-[(2,5-dichlorophenyl)met |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) activity (Ki = 0.4 μM). Causes cell death through the apoptosis pathway; increases levels of highly ubiquitinated proteins and decreases ubiquitin proteasome activity. Activity leads to dramatic alterations in synaptic protein distribution and spine morphology in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 397.64 |
| 分子式 | C17H11Cl3N2O3 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| CAS号 | 668467-91-2 |
| 参考文献 | Cartieret al (2009) Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1. J.Neurosci. 29 7857. PMID: 19535597. Tanet al (2008) Endoplasmic reticulum stress contributes to the cell death induced by UCH-L1 inhibitor. Mol.Cell.Biochem. 318 109. PMID: 18622688. Liuet al (2003) Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem.Biol. 10 837. PMID: 14522054. |