| 货号 | 0729/50 |
| 别名 | 5-[2-(Imidazol-4-yl)ethyl]isothiour |
| 供应商 | Tocris |
| 生物活性 | An extremely potent, high affinity agonist at H3 and H4 receptors (Ki values are 0.3 and 2.7 nM respectively). Induces shape change in eosinophils with an EC50 of 25 nM. Centrally active following systemic administration. Also available as part of the Histamine H3 Receptor Tocriset™. |
| 运输条件 | Ambient |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 332.06 |
| 分子式 | C6H10N4S.2HBr |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| CAS号 | 32385-58-3 |
| 参考文献 | Linget al (2004) Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation. Br.J.Pharmacol. 142 161. PMID: 15131002. Farzin and Attarzadeh (2000) Influence of different histamine receptor agonists and antagonists on apomorphine-induced licking behavior in rats. Eur.J.Pharmacol. 404 169. PMID: 10980276. Garbarget al (1992) S-[2-(4-Imidazolyl)ethyl]isothiourea, a highly specific and potent histamine H3 receptor agonist. J.Pharmacol.Exp.Ther. 263 304. PMID: 1383495. |