| 货号 | 1531/50 |
| 别名 | 3,4-Dihydro-3-(2-hydroxyphenyl)-6-( |
| 供应商 | Tocris |
| 生物活性 | Cooling agent that activates the novel cold receptors TRPM8 (CMR1) and TRPA1 (ANKTM1/TRPN1), members of the TRP ion channel family. Induces currents in CMR1-expressing HEK 293 cells (EC50 = 0.36 μM) more potently than menthol or low temperatures. Produces "wet shakes" in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 311.3 |
| 分子式 | C16H13N3O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 36945-98-9 |
| 参考文献 | Behrendtet al (2004) Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br.J.Pharmacol. 141 737. PMID: 14757700. Storyet al (2003) ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell 112 819. PMID: 12654248. McKemyet al (2002) Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature 416 52. PMID: 11882888. Weiet al (1983) AG-3-5: a chemical producing sensations of cold. J.Pharm.Pharmacol. 35 110. PMID: 6131976. |