| 货号 | 5283/50 |
| 别名 | 7-[(4-Ethoxy-3-methylphenyl)(2-pyri |
| 供应商 | Tocris |
| 生物活性 | E2F transcription factor inhibitor; inhibits E2F DNA binding activity. Inhibits E2F4 DNA binding and reduces E2F4 protein levels in A375 melanoma cells. Induces apoptosis of A375 and MDA-MB-231 breast cancer cells. Inhibits A375 proliferation and invasion in a three dimensional skin model of A375 invasion. Also attenuates human embryonic stem cell proliferation. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 399.48 |
| 分子式 | C25H25N3O2 |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO |
| 参考文献 | Conklinet al (2012) The RB family is required for the self-renewal and survival of human embryonic stem cells. Nat.Commun. 3 1244. PMID: 23212373. Maet al (2008) A small-molecule E2F inhibitor blocks growth in a melanoma culture model. Cancer Res. 68 6292. PMID: 18676853. |