| 货号 | 5673/50 |
| 别名 | 5-[[3-Methoxy-4-[(4-methoxyphenyl)m |
| 供应商 | Tocris |
| 生物活性 | Potent and selective cFMS kinase inhibitor (IC50 = 0.06 μM). Exhibits selectivity for cFMS kinase over 186 other kinases. Inhibits CSF-1-induced growth of rat monocytes in vitro. Also inhibits bone resorption in osteoclast cultures, as well as connective tissue and bone destruction in a rat adjuvant arthritis model. Suppresses M-NFS-60 tumor cell growth in mice. Orally bioavailable. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 366.41 |
| 分子式 | C20H22N4O3 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| 参考文献 | Conwayet al (2008) Effects of the cFMS kinase inhibitor 5-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine (GW2580) in normal and arthritic rats. J.Pharmacol.Exp.Ther. 326 41. PMID: 18434589. Conwayet al (2005) Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580. Proc.Natl.Acad.Sci.U.S.A. 102 16078. PMID: 16249345. |