| 货号 | 1403/50 |
| 别名 | 2,5-Dimethyl-4-[2-(phenylmethyl)ben |
| 供应商 | Tocris |
| 生物活性 | Potent activator of L-type Ca2+ channels (EC50 = 16 nM). 40-fold more potent than Bay K 8644 (Cat. No. 1544) as a positive inotrope in guinea pig atria. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 347.41 |
| 分子式 | C22H21NO3 |
| 可溶性/溶解性 | Soluble to 25 mM in ethanol and to 50 mM in DMSO |
| CAS号 | 120934-96-5 |
| 参考文献 | Baxteret al (1993) Discovery and synthesis of methyl 2,5-dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylate (FPL 64176) and analogues: the first examples of a new class of calcium channel activator. J.Med.Chem. 36 2739. PMID: 7692047. Rampeet al (1993) Comparison of the in vitroandin vivo cardiovascular effects of two structurally distinct Ca++ channel activators, BAY K 8644 and FPL 64176. J.Pharmacol.Exp.Ther. 265 1125. PMID: 7685384. Zhenget al (1991) Pharmacological, radioligand binding, and electrophysiological characteristics of FPL 64176, a novel nondihydropyridine Ca2+ channel activator, in cardiac and vascular preparations. Mol.Pharmacol. 40 734. PMID: 1719369. |