| 货号 | 0658/50 |
| 别名 | N,N-Dihexyl-2-(4-fluorophenyl)indol |
| 供应商 | Tocris |
| 生物活性 | Binds specifically and with high affinity to the peptide DBI receptor (benzodiazepine receptor) on mitochondrial membranes, inducing production of neurosteroids, which modulate GABA receptors (EC50 = 3 nM for increase in production of pregnenolone in glial cells). Thus it reduces anxiety without causing sedation. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 436.61 |
| 分子式 | C28H37FN2O |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 142720-24-9 |
| 参考文献 | Kozikowskiet al (1992) Synthesis of (2-arylindol-3-yl)acetamides as probes for mitochondrial steroidogenesis - a new mechanism of GABAA receptor modulation. Angew.Chem.Int.Ed. 311060. Romeoet al (1992) 2-Aryl-3-indoleacetamides (FGIN-1): a new class of potent and specific ligands for the mitochondrial DBI receptor (MDR). J.Pharmacol.Exp.Ther. 262 971. PMID: 1326631. |