| 货号 | 5601/50 |
| 别名 | 5,6-Dimethyl-9-oxo-9H-xanthene-4-ac |
| 供应商 | Tocris |
| 生物活性 | mSTING agonist; selective for mouse STING over human STING. Induces IFN-β and cytokine production from bone marrow-derived dendritic cells. Causes tumor regression following intratumoral administration in mouse tumor models. Induces an adaptive immune response to reduce systemic tumor growth and provides immunological memory against autologous tumor re-challenge. Also antiviral. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 282.29 |
| 分子式 | C17H14O4 |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO |
| 参考文献 | Corraleset al (2015) Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity. Cell Rep. 11 1018. PMID: 25959818. Shireyet al (2011) The anti-tumor agent, 5,6-dimethylxanthenone-4-acetic acid (DMXAA), induces IFN-β-mediated antiviral activity in vitroandin vivo. J.Leukoc.Biol. 89 351. PMID: 21084628. Phillips (1999) Inhibition of DT-diaphorase (NAD(P)H:quinone oxidoreductase, EC 1.6.99.2) by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and flavone-8-acetic acid (FAA): implications for bioreductive drug development. Biochem.Pharmacol. 58 303. PMID: 10423172. |