| 货号 | 3683/50 |
| 别名 | 6-(4-Chlorophenyl)imidazo[2,1-b][1, |
| 供应商 | Tocris |
| 生物活性 | Constitutive androstane receptor (CAR) agonist (EC50 = 49 nM). Displays > 100-fold selectivity over PXR receptors and no activity at LXR, ERα, ERβ, PPAR, RAR, FXR, VDR and THR. Induces CAR nuclear translocation and expression of CYP2B6 in hepatocytes in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 436.74 |
| 分子式 | C19H12Cl3N3OS |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO and to 5 mM in ethanol |
| 参考文献 | Clenet al (2009) A single amino acid controls the functional switch of human CAR1 to the xenobiotic sensitive splicing variant CAR3. J.Pharmacol.Exp.Ther. 332 106. PMID: 19820207. Moreauet al (2007) Constitutive androstane receptor-vitamin D receptor crosstalk: consequence on CYP24 gene expression. Biochem.Biophys.Res.Comm. 36076. Maglichet al (2003) Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes. J.Biol.Chem. 278 17277. PMID: 12611900. |