| 货号 | 0725/50 |
| 别名 | 2-(4,5-Dihydroimidazol-2-yl)quinoli |
| 供应商 | Tocris |
| 生物活性 | High affinity ligand for the imidazoline I2 binding site (Ki = 2.1 nM). Putative I2 antagonist; antagonizes the effects of imidazoline ligands on morphine antinociception. Produces ipsiversive rotational behavior in rats with a full 6-OHDA lesion of the nigrostriatal tract. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 计算分子量 | 233.7 |
| 分子式 | C12H11N3.HCl |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO |
| CAS号 | 187173-05-3 |
| 参考文献 | MacInnes and Dut (2004) Locomotor effects of imidazoline I2-site-specific ligands and monoamine oxidase inhibitors in rats with a unilateral 6-hydroxydopamine lesion of the nigrostriatal pathway. Br.J.Pharmacol. 143 952. PMID: 15545290. Sanchez-Blasquezet al (2000) Activation of I2-imidazoline receptors enhances supraspinal morphine analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br.J.Pharmacol. 130 146. PMID: 10781010. Hudsonet al (1999) Novel selective compounds for the investigation of imidazoline receptors. Ann.N.Y.Acad.Sci. 881 81. PMID: 10415900. Hudsonet al (1994) Affinity and selectivity of BU224 and BU239 for rabbit brain non-adrenoceptor idazoxan binding sites (I2) sites). Br.J.Pharmacol. 112320P. |