| 货号 | 2322/50 |
| 别名 | 1-(4-Chlorophenyl)-α-(2-methylpropyl |
| 供应商 | Tocris |
| 生物活性 | Potently active primary amine metabolite of sibutramine (Cat. No. 2290), exhibits a similar pharmacological profile to the parent compound. Inhibits serotonin and noradrenalin reuptake more potently than sibutramine in vitro. Reduces food intake in rodents following i.c.v. administration and increases energy expenditure via thermogenesis in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 288.26 |
| 分子式 | C15H22NCl.HCl |
| 可溶性/溶解性 | Soluble to 50 mM in water and to 100 mM in DMSO |
| CAS号 | 84484-78-6 |
| 参考文献 | Liuet al (2002) Mechanism of the thermogenic effect of Metabolite 2 (BTS 54 505), a major pharmacologically active metabolite of the novel anti-obesity drug, sibutramine. Int.J.Obes.Relat.Metab.Disord. 26 1245. PMID: 12187403. Gundlahet al(1997)In vivo criteria to differentiate monoamine reuptake inhibitors from releasing agents: sibutramine is a reuptake inhibitor. J.Pharmacol.Exp.Ther. 283 581. PMID: 9353373. Luscombeet al (1989) The contribution of metabolites to the rapid and potent down-regulation of rat cortical beta-adrenoceptors by the putative antidepressant sibutramine hydrochloride. Neuropharmacology 28 129. PMID: 2541365. |