| 货号 | 3221/50 |
| 别名 | 1,1'-(1,12-Dodecanediyl)bis[3-methyl |
| 供应商 | Tocris |
| 生物活性 | Orthosteric neuronal nicotinic acetylcholine receptor (nAChR) antagonist (IC50 values are 0.17, 0.25, 0.4, 4.8, 6.5, 8.2, 20 and 34 μM at α3β4,α1β1εδ,α3β4β3,α6β4β3,α7,α4β2,α3β2β3 and α6/3β2β3 receptors respectively). Attenuates nicotine-evoked dopamine release from the ventral tegmental area in vivo(IC50 = 0.2 nM) and reduces nicotine self-administration in rats. Brain penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 514.38 |
| 分子式 | C24H38Br2N2< |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in DMSO |
| 参考文献 | Dwoskinet al(2008)N,N'alkane-diyl-bis-3-picoliniums as nicotinic receptor antagonists: Inhibition of nicotine-evoked dopamine release and hyperactivity. J.Pharmacol.Exp.Ther. 326 563. PMID: 18460644. Rahmanet al (2008) Region-specific effects of the N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide on nicotine-induced increase in extracellular dopamine in vivo. Br.J.Pharmacol. 153 792. PMID: 18059317. Ayerset al (2002) Bis-azaaromatic quaternary ammonium analogues: ligands for α4β2* and β7* subtypes of neuronal nicotinic receptors Bioorg.Med.Chem.Letts. 123067. |