| 货号 | 1440/50 |
| 别名 | α-(4-Fluorophenyl)-4-(5-fluoro-2-pyr |
| 供应商 | Tocris |
| 生物活性 | Potent sigma receptor antagonist (IC50 = 112 nM) with modest to weak affinity for 5-HT1Aandα1 receptors. Antipsychotic following oral administration and acts via indirect modulation of central dopaminergic systems. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 384.86 |
| 分子式 | C18H22F2N4O.HCl |
| 可溶性/溶解性 | Soluble to 25 mM in water |
| CAS号 | 105565-55-7 |
| 参考文献 | Tayloret al (1993) A role for sigma binding in the antipsychotic profile of BMY 14802? NIDA Res.Monogr. 133 125. PMID: 8232511. Zhanget al (1993) Further characterization of the effects of BMY 14802 on dopamine neuronal activity. Synapse 15 276. PMID: 7908761. Yevichet al (1992) Synthesis and biological characterization of α-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol and analogues as potential atypical antipsychotic agents. J.Med.Chem. 35 4516. PMID: 1361578. |