| 货号 | 0485/50 |
| 别名 | 1,3-Dioxo-1H-benz[d,e]isoquinoline- |
| 供应商 | Tocris |
| 生物活性 | Specific inhibitor of aldose reductase (IC50 = 148 μM). Attenuates glucose-induced angiotensin II production in rat vascular smooth muscle in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 计算分子量 | 255.23 |
| 分子式 | C14H9NO4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 51411-04-2 |
| 参考文献 | Lavrentyevet al (2007) Mechanism of high glucose-induced angiotensin II production in rat vascular smooth muscle cells. Circ.Res. 101 455. PMID: 17626897. Barskiet al (1996) The C-terminal loop of aldehyde reductase determines the substrate and inhibitor specificity. Biochemistry 35 14276. PMID: 8916913. Ehriget al (1994) Mechanism of aldose reductase inhibition: binding of NADP+/NADPH and alrestatin-like inhibitors. Biochemistry 33 7157. PMID: 8003482. |