| 货号 | 1555/50 |
| 别名 | (E)-3-[3-[2-Benzothiazolythio)methy |
| 供应商 | Tocris |
| 生物活性 | Selective ErbB2 inhibitor (IC50 values are 0.15 and 19 μM at ErbB2 and ErbB1 respectively). Preferentially triggers p38 MAP kinase-dependent apoptosis in androgen-independent prostate cancer cells. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 计算分子量 | 397.47 |
| 分子式 | C19H15N3O3S2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 149092-50-2 |
| 参考文献 | Murilloet al (2001) Tyrphostin AG825 triggers p38 mitogen-activated protein kinase-dependent apoptosis in androgen-independent prostate cancer cells C4 and C4-21. Cancer Res. 61 7408. PMID: 11606371. Gazitet al (1993) Tyrphostins. 3. Structure-activity relationship studies of α-substituted benzylidenemalononitrile 5-S-aryltyrphostins. J.Med.Chem. 36 3556. PMID: 7902440. Osherovet al (1993) Selective inhibition of the epidermal growth factor and HER2/Neu receptors by tyrphostins. J.Biol.Chem. 268 11134. PMID: 8098709. |