| 货号 | 0619/50 |
| 别名 | (E)-2-Cyano-3-(3,4-dihydroxyphenyl) |
| 供应商 | Tocris |
| 生物活性 | Potent inhibitor of epidermal growth factor receptor (EGFR) kinase (IC50 = 0.7 μM). Selective over ErbB2, PDGFR and insulin receptor kinase (IC50 values are 42, 6 and > 100 μM respectively). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 计算分子量 | 280.28 |
| 分子式 | C16H12N2O3 |
| 可溶性/溶解性 | Soluble to 5 mM in ethanol and to 50 mM in DMSO |
| CAS号 | 133550-35-3 |
| 参考文献 | Tomlinset al (2005) Cross-talk between the calcium-sensing receptor and the epidermal growth factor receptor in Rat-1 fibroblasts. Exp.Cell Res. 308 439. PMID: 15950968. Ben-Bassatet al (1999) Tyrphostins that suppress the growth of human papilloma virus 16-immortalized human keratinocytes. J.Pharmacol.Exp.Ther. 290 1442. PMID: 10454524. Gazitet al (1991) Tyrphostins. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrophostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. J.Med.Chem. 34 1896. PMID: 1676428. |