| 货号 | 0569/50 |
| 别名 | (R)-(-)-α-Methyl-1H-imidazole-4-etha |
| 供应商 | Tocris |
| 生物活性 | Very potent, high affinity H3 agonist (KD = 50.3 nM) that displays > 200-fold selectivity over H4 receptors. Inhibits H3-mediated histamine synthesis and release in the CNS and stimulates H4-mediated eosinophil shape change (EC50 = 66 nM). Part of the Histamine H3 Receptor Tocriset™. (S)-(+)-α-Methylhistamine dihydrobromide (Cat. No. 0572) also available. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 287 |
| 分子式 | C6H11N3.2HBr |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| CAS号 | 75614-87-8 |
| 参考文献 | Shahidet al (2009) Histamine, histamine receptors, and their role in immunomodulation: An updated systematic review. Open Immunol.J. 29. Bucklandet al (2003) Histamine induces cytoskeletal changes in human eosinophils via the H4 receptor. Br.J.Pharmacol. 140 1117. PMID: 14530216. Hewet al (1990) Characterization of histamine-H3 receptors in guinea pig ileum with H3-selective ligands. Br.J.Pharmacol. 101 621. PMID: 1963802. Schwartzet al (1990) A third histamine receptor subtype - characterization, localization and functions of the H3-receptor. Agents Actions 30 13. PMID: 1695431. Oishiet al (1989) Effects of histamine H3-agonist (R)-α-methylhistamine and the antagonist thioperamide on histamine modulation in the mouse and rat brain. J.Neurochem. 52 1388. PMID: 2540269. |