| 货号 | 10118-10mg |
| 描述 | Many of the effects of prostaglandin D2(PGD2) are transduced via a traditional 7-transmembrane GPCR, the DP1receptor.1 However, in certain leukocytes and other immune cells, a second PGD2 receptor referred to as the CRTH2 or DP2 receptor has been cloned and characterized.2,3 15(R)-15-methyl PGD2 is a surprisingly potent agonist at the DP2 receptor, being about 5 times more potent than PGD2itself.415(R)-PGD2 has the potential to be produced endogenously as a natural ligand for DP2, unlike the synthetic 15-methyl analogs. In preliminary reports, 15(R)-PGD2 has also been reported to be a potent and selective DP2 receptor agonist.5,6 |
| 别名 | 15(R)-PGD2; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Boie, Y.,Sawyer, N.,Slipetz, D.M., et al. Molecular cloning and characterization of the human prostanoid DP receptor. The Journal of Biological Chemisty 270, 18910-18916 (1995). 2.Abe, H.,Takeshita, T.,Nagata, K., et al. Molecular cloning, chromosome mapping and characterization of the mouse CRTH2 gene, a putative member of the leukocyte chemoattractant receptor family. Gene 227, 71-77 (1999). 3.Hirai, H.,Tanaka, K.,Yoshie, O., et al. Prostaglandin D2 selectivity induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. Journal of Experimental Medicine 193(2), 255-261 (2001). 4.Monneret, G.,Cossette, C.,Gravel, S., et al. 15R-methyl-prostaglandin D2 is a potent and selective CRTH2/DP2 receptor agonist in human eosinophils. Journal of Pharmacology and Experimental Therapeutics 304(1), 349-355 (2003). 5.Kim, S.,Bellone, S.,Maxey, K.M., et al. Synthesis of 15R-PGD2: A potential DP2 receptor agonist. Bioorganic & Medicinal Chemistry Letters 15, 1873-1876 (2005). 6.Cossette, C.,Walsh, S.E.,Kim, S., et al. Agonist and antagonist effects of 15R-prostaglandin (PF) D2 and 11-methylene-PGD2 on human eosinophils and basophils. Journal of Pharmacology and Experimental Therapeutics 320(1), 173-179 (2007). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 352.5 |
| 分子式 | C20H32O5 |
| CAS号 | 59894-05-2 |
| 稳定性 | ≥ 1 year |
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