| 货号 | 15558-5g |
| 描述 | Angiotensin-converting enzyme (ACE) removes the C-terminal dipeptide from angiotensin I to form angiotensin II, a powerful vasoconstrictor. ACE is a key regulator of the renin-angiotensin system and an important drug target for the treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications in diabetes.1 Ramipril is a second generation ACE inhibitor (IC50 = 4 nM) that acts as a prodrug, which is hydrolyzed in vivo to the active metabolite ramiprilat.2,3 The antihypertensive and cardioprotective efficacy of ramipril has been demonstrated in large-scale noncomparative studies and clinical trials.4 |
| 别名 | Altace;HOE 498; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Zaman, M.A.,Oparil, S. and Calhoun, D.A. Drugs targeting the renin-angiotensin-aldosterone system. Nature Reviews.Drug Discovery 1, 621-636 (2002). 2.Leung, D.,Abbenante, G. and Fairlie, D.P. Protease inhibitors: Current status and future prospects. J. Med. Chem. 43(3), 305-341 (2000). 3.Levitt, D.G. and Schoemaker, R.C. Human physiologically based pharmacokinetic model for ACE inhibitors: Ramipril and ramiprilat. BMC Clin.Pharmacol. 6(1), (2006). 4.Yusuf, S.,Sleight, P.,Pogue, J., et al. Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. New England Journal of Medicine 342(3), 145-153 (2000). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 416.5 |
| 分子式 | C23H32N2O5 |
| CAS号 | 87333-19-5 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |