| 货号 | 21884-250mg |
| 描述 | 3-Acetylpyridine NAD (APAD) is an analog of NAD+ (free acid) (nicotinamide adenine dinucleotide; Item No. 16077), a signaling molecule and cofactor or substrate for many enzymes.1,2 APAD has been used to study the mechanisms of oxidative phosphorylation.3 It can be reduced by transdehydrogenase from NADH (sodium salt) (Item No. 16078).4 It can be reduced more efficiently and is more stable than NAD+; thus, it is useful as a substitute.5 |
| 别名 | APAD;NSC 20275; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Houtkooper, R.H.,Cantó, C.,Wanders, R.J., et al. The secret life of NAD+: An old metabolite controlling new metabolic signaling pathways. Endocr. Rev. 31(2), 194-223 (2010). 2.Ciaccio, E.I. The inhibition of lactate dehydrogenase by 3-acetylpyridine adenine dinucleotide and bisulfite. J. Biol. Chem. 241(7), 1581-1586 (1966). 3.Birrell, J.A. and Hirst, J. Investigation of NADH binding, hydride transfer, and NAD(+) dissociation during NADH oxidation by mitochondrial complex I using modified nicotinamide nucleotides. Biochemistry 52(23), 4048-4055 (2013). 4.Stilwell, S.N.,Bizouam, T. and Jackson, J.B. The reduction of acetylpyridine adenine dinucleotide by NADH: is it a significant reaction of proton-translocating transhydrogenase, or an artefact? Biochim Biophys. Acta. 1320(1), 83-94 (1997). 5.Lee, H.J.,Lee, S.H.,Park, C.B., et al. Coenzyme analogs: Excellent substitutes (not poor imitations) for electrochemical regeneration. Chem. Commun. (Camb.) 47(46), 12538-12540 (2011). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 662.4 |
| 分子式 | C22H28N6O14P2 |
| CAS号 | 86-08-8 |
| 稳定性 | ≥ 2 years |
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