AZD 5438
货号：
21598-50mg 基本售价：
7882.0 元 规格：
50 mg
产品信息
概述| 货号 | 21598-50mg |
| 描述 | AZD 5438 is a potent inhibitor of the cyclin-dependent kinases (CDKs) 1, 2, and 9 (IC50s = 16, 6, and 20 nM, respectively).1 AZD 5438 also inhibits the kinase activity of Cdk5/p25 and glycogen synthase kinase 3β (GSK3β) (IC50s = 14 and 17 nM, respectively). AZD 5438 induces cell cycle arrest by inhibiting phosphorylation of CDK-dependent substrates and exhibits in vitro antiproliferative activity against a range of tumor cell lines including lung, colorectal, breast, prostate, and hematologic tumors with IC50s ranging from 200 nM (MCF-7) to 1700 nM (ARH-77).1,2 AZD 5438 inhibits growth of human tumor xenografts derived from a wide range of cancer types and inhibits cell cycle proteins.1,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Byth, K.F.,Thomas, A.,Hughes, G., et al. AZD5438, a potent oral inhibitor of cyclin-dependent kinases 1, 2, and 9, leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts. Mol. Cancer. Ther. 8(7), 1856-1866 (2009).
2.Raghavan, P.,Tumati, V.,Yu, L., et al. AZD5438, an inhibitor of Cdk1, 2, and 9, enhances the radiosensitivity of non-small cell lung carcinoma cells. Int. J. Radiat. Oncol. Biol. Phys. 84(4), e507-e514 (2012).
3.Dickson, M.A. and Schwartz, G.K. Development of cell-cycle inhibitors for cancer therapy. Curr. Oncol. 16(2), 36-43 (2009).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 371.5 |
| 分子式 | C18H21N5O2S |
| CAS号 | 602306-29-6 |
| 稳定性 | ≥ 2 years |
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