| 货号 | 12060-10mg |
| 描述 | BW A868C is a hydantoin compound that is structurally related to the DP receptor agonist BW 245C.1,2 BW A868C antagonizes the prostaglandin D2 and BW 245C-induced activation of human platelet adenylate cyclase. It reverses the anti-aggregatory effects of DP receptor agonists in a dose-dependent manner. Likewise, BW A868C antagonizes the accumulation of cAMP in rabbit non-pigmented ciliary epithelial cells.3 It has virtually no effect on human TP, IP, EP1, EP2, and FP receptors. The Ki for BW A868C is approximately 1.7 nM.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Caldwell, A.G.,Harris, C.J.,Stepney, R., et al. Hydantoin prostaglandin analogues, potent and selective inhibitors of platelet aggregation. Journal of the Chemical Society.Chemical Communications 561-562 (1979). 2.Trist, D.G.,Collins, B.A.,Wood, J., et al. The antagonism by BW A868C of PGD2 and BW245C activation of human platelet adenylate cyclase. British Journal of Pharmacology 96, 301-306 (1989). 3.Bhattacherjee, P.,Jacobs, N.,Coca-Prados, M., et al. Identification of prostanoid receptors in rabbit non-pigmented ciliary epithelial cells. Experimental Eye Research 62, 491-498 (1996). 4.Giles, H.,Leff, P.,Bolofo, M.L., et al. The classification of prostaglandin DP-receptors in platelets and vasculature using BW A868C, a novel, selective and potent competitive antagonist. British Journal of Pharmacology 96, 291-300 (1989). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 459.6 |
| 分子式 | C25H37N3O5 |
| CAS号 | 118675-50-6 |
| 稳定性 | ≥ 1 year |
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