| 货号 | 11332-10mg |
| 描述 | Fumagillin is an antibiotic derived from the fungus A. fumigatus. It binds and inhibits methionine aminopeptidase-2 with an IC50 value of 10 nM.1,2 Fumagillin inhibits angiogenesis by impairing the growth of endothelial cells and altering gene expression.1,3,4 It also impairs microsporidial replication and can be used to treat both conjunctival and intestinal microsporidial infections in immunocompromised patients.5,6 Finally, fumagillin reduces diet-induced adipose tissue formation in mice, independent of its effects on angiogenesis.7 |
| 别名 | Amebacilin;NSC 9168; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Griffith, E.C.,Su, Z.,Niwayama, S., et al. Molecular recognition of angiogenesis inhibitors fumagillin and ovalicin by methionine aminopeptidase 2. Proceedings of the National Academy of Sciences of the United States of America 95, 15183-15188 (1998). 2.Lowther, W.T.,McMillen, D.A.,Orville, A.M., et al. The anti-angiogenic agent fumagillin covalently modifies a conserved active-site histidine in the Escherichia coli methionine aminopeptidase. Proceedings of the National Academy of Sciences of the United States of America 95, 12153-12157 (1998). 3.Mazzanti, C.M.,Tandle, A.,Lorang, D., et al. Early genetic mechanisms underlying the inhibitory effects of endostatin and fumagillin on human endothelial cells. Genome Research 14, 1585-1593 (2004). 4.Sheen, I.S.,Jeng, K.S.,Jeng, W.J., et al. Fumagillin treatment of hepatocellular carcinoma in rats: An in vivo study of antiangiogenesis. World Journal of Gastroenterology 11(6), 771-777 (2005). 5.Didier, E.S.,Rogers, L.B.,Brush, A.D., et al. Diagnosis of disseminated microsporidian Encephalitozoon hellem infection by PCR-southern analysis and successful treatment with albendazole and fumagillin. Journal of Clinical Microbiology 34(4), 947-952 (1996). 6.Molina, J.M.,Tourneur, M.,Sarfati, C., et al. Fumagillin treatment of intestinal microsporidiosis. New England Journal of Medicine 346(25), 1963-1969 (2002). 7.Lijnen, H.R.,Frederix, L. and Van Hoef, B. Fumagillin reduces adipose tissue formation in murine models of nutritionally induced obesity. Obesity 18, 2241-2246 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 458.6 |
| 分子式 | C26H34O7 |
| CAS号 | 23110-15-8 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |