17-chlorophenyl trinor Prostaglandin F2α ethyl amide
货号：
10010460-10mg 基本售价：
7840.0 元 规格：
10 mg
产品信息
概述| 货号 | 10010460-10mg |
| 描述 | Prostaglandin F2α(PGF2α) drives luteolysis and smooth muscle contraction by activating the FP receptor. In addition, PGF2α can activate the PGE2 receptor EP1, albeit at higher concentrations, evoking inflammatory effects.1,2 Replacement of the ω-terminal three carbons with a phenyl group, producing 17-phenyl PGF2α, gives a ligand with both greater affinity for FP and diminished affinity for EP1.1 Compounds based on this structure are effective in lowering intraocular pressure, reducing ocular hypertension and limiting the progression of glaucoma. 17-phenyl PGF2α ethyl amide (Bimatoprost) is a prodrug which, after entering the cornea, is hydrolyzed to give the corresponding free acid.3 17-chlorophenyl trinor Prostaglandin F2α ethyl amide has a chlorine atom substituted into the meta position of the phenyl group of 17-phenyl PGF2α ethyl amide. The meta substitution of a halogen (fluorine) at this site on the free acid increases its affinity for the FP receptor and greatly decreases its affinity for the EP1receptor.1 |
| 别名 | Chlorophenyl Bimatoprost;17-chlorophenyl trinor PGF2α ethyl amide; |
性能| 供应商 | Cayman |
| 应用文献 |
1.deLong, M.A.,Amburgey, J.,Taylor, C., et al. Synthesis and in vitro evaluation of human FP-receptor selective prostaglandin analogues. Bioorganic & Medicinal Chemistry Letters 10, 1519-1522 (2000).
2.Negishi, M.,Sugimoto, Y. and Ichikawa, A. Prostanoid receptors and their biological actions. Progress in Lipid Research 32, 417-434 (1993).
3.Maxey, K.M.,Johnson, J.,Camras, C.B., et al. The hydrolysis of bimatoprost in corneal tissue generates a potent prostanoid FP receptor agonist. Survey of Ophthalmology 47(4), 34-40 (2002).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 450.1 |
| 分子式 | C25H36ClNO4 |
| 稳定性 | ≥ 1 year |
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