| 货号 | 6001/50 |
| 别名 | 2-(Hexylthio)-6-hydroxy-4(3H)-pyrim |
| 供应商 | Tocris |
| 生物活性 | Selective medium-chain free fatty acid receptor GPR84 agonist (EC50 = 139 nM). Exhibits no response at GPR40, GPR41, GPR119 or GPR120 at 100 uM. Activates calcium mobilization, inhibits cAMP accumulation, and induces ERK1/2 phosphorylation, receptor desensitization and internalization in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 228.31 |
| 分子式 | C10H16N2O2 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO and to 100 mM in ethanol |
| 参考文献 | Liuet al (2016) Design and synthesis of 2-alkylpyrimidine-4,6-diol and 6-alkylpyridine-2,4-diol as potent GPR84 agonists. ACS Med.Chem.Lett. 7 579. PMID: 27326330. Zhanget al (2016) Discovery and characterization of a novel small-molecule agonist for medium-chain free fatty acid receptor G protein-coupled receptor 84. J.Pharmacol.Exp.Ther. 357 337. PMID: 26962172. |