| 货号 | 0497/50 |
| 别名 | (E)-2-Cyano-3-(3,4-dihydroxyphenyl) |
| 供应商 | Tocris |
| 生物活性 | Epidermal growth factor receptor (EGFR) kinase inhibitor (IC50 = 10 μM) that is selective over insulin receptor kinase. Blocks tyrosine phosphorylation of p145met and promotes cell death of normal and cancer cells via activation of caspase-like proteases in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 204.18 |
| 分子式 | C10H8N2O3 |
| 可溶性/溶解性 | Soluble to 5 mM in ethanol and to 100 mM in DMSO |
| CAS号 | 122520-85-8 |
| 参考文献 | Yamamotoet al (2006) Tyrosine phosphorylation of p145met mediated by EGFR and Src is required for serum-independent survival of human bladder carcinoma cells. J.Cell Sci. 119 4623. PMID: 17062641. Gazit (1996) Tyrphostins. 6. Dimeric benzylidenemalononitrile tyrphostins: potent inhibitors of EGF receptor tyrosine kinase in vitro. J.Med.Chem. 39 4905. PMID: 8960549. Levitzki and Gilon (1991) Tyrphostins as molecular tools and potential antiproliferative drugs. TiPS 12 171. PMID: 1862529. Gazitet al (1989) Tyrphostins. I. Synthesis and biological activity of protein tyrosine kinase inhibitors. J.Med.Chem. 32 2344. PMID: 2552117. |