| 货号 | 0493/50 |
| 别名 | [(3,4-Dihydroxyphenyl)methylene]-pr |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR) kinase (IC50 values are 35 and 25 μM respectively). Inhibits EGF-stimulated cell proliferation. Also acts as a mitochondrial uncoupler that alters phosphorylation-dependent cell signaling. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 计算分子量 | 186.17 |
| 分子式 | C10H6N2O2 |
| CAS号 | 118409-57-7 |
| 参考文献 | Soltoff (2004) Evidence that tyrphostins AG10 and AG18 are mitochondrial uncouplers that alter phosphorylation-dependent cell signaling. J.Biol.Chem. 279 10910. PMID: 14688271. Levitzki and Gazit (1995) Tyrosine kinase inhibition: an approach to drug development. Science 267 1782. PMID: 7892601. Gazitet al (1989) Tyrphostins inhibit epidermal growth factor (EGF)-receptor tyrosine kinase activity in living cells and EGF-stimulated cell proliferation. J.Biol.Chem. 264 14503. PMID: 2788167. Gazitet al (1989) Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. J.Med.Chem. 32 2344. PMID: 2552117. Gazitet al (1988) Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors. Science 242 933. PMID: 3263702. |