5-cis Carbaprostacyclin
货号：
18211-5mg 基本售价：
7812.0 元 规格：
5 mg
产品信息
概述| 货号 | 18211-5mg |
| 描述 | 5-cis Carbaprostacyclin is a stable analog of PGI2 and an isomer of carbaprostacyclin. It is a weak inhibitor of human platelet aggregation with an IC50 of 2.8 µM compared to 0.3 µM for carbaprostacyclin.1,25-cis Carbaprostacyclin is a much weaker effector of rabbit mesenteric artery relaxation with an EC50 of 104 µM compared to 5.9 µM for carbaprostacyclin. It even antagonizes the adenylate cyclase activation induced by carbaprostacyclin.2 |
| 别名 | (5Z)-6a-Carbaprostaglandin I2; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Whittle, B.J.R.,Moncada, S.,Whiting, F., et al. Carbacyclin - a potent stable prostacyclin analogue for the inhibition of platelet aggregation. Prostaglandins 19, 605-627 (1980).
2.Corsini, A.,Folco, G.C.,Fumagalli, R., et al. (5Z)-carbacyclin discriminates between prostacyclin-receptors coupled to adenylate cyclase in vascular smooth muscle and platelets. British Journal of Pharmacology 90, 255-261 (1987).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% |
| 计算分子量 | 350.5 |
| 分子式 | C21H34O4 |
| CAS号 | 69609-77-4 |
| 稳定性 | ≥ 1 year |
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