TCS PIM-1 1
货号：
16286-100mg 基本售价：
7742.0 元 规格：
100 mg
产品信息
概述| 货号 | 16286-100mg |
| 描述 | The proto-oncogene serine/threonine-protein kinases, Pim-1 and Pim-2, are enzymes involved in cytokine signaling and participate in various signal transduction pathways, including cell growth, differentiation, and apoptosis. Their overexpression has been implicated in prostate cancer, some forms of leukemia, and lymphoma. TCS PIM-1 1 is an ATP-competitive Pim-1 kinase inhibitor (IC50 = 50 nM) that displays selectivity over the related kinases, Pim-2 and MEK1/2 (IC50s = >20 µM).1 |
| 别名 | Pim-1 Kinase Inhibitor II;SC-204330; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Cheney, I.W.,Yan, S.,Appleby, T., et al. Identification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase. Bioorganic & Medicinal Chemistry Letters 17(6), 1679-1683 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 367.2 |
| 分子式 | C18H11BrN2O2 |
| CAS号 | 491871-58-0 |
| 稳定性 | ≥ 2 years |
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