SB-269970 (hydrochloride)
货号：
17081-50mg 基本售价：
7728.0 元 规格：
50 mg
产品信息
概述| 货号 | 17081-50mg |
| 描述 | The transduction of neurobehavioral effects by serotonin (5-hydroxy tryptamine; 5-HT) is mediated by at least seven major 5-HT receptor subtypes. SB-269970 is a potent 5-HT7A antagonist (pKi = 8.9) that demonstrates >50-fold binding selectivity over 5-HT5A and >250-fold selectivity over 5-HT1, 5-HT2, 5-HT4, 5-HT6, adrenergic α1, dopamine D2, and dopamine D3receptors.1 It is also reported to block adrenergic α2 receptors in guinea pig vas deferens.2 SB-269970 has been used to target the 5-HT7 receptor in the study of schizophrenia-like cognitive deficits.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lovell, P.J.,Bromidge, S.M.,Dabbs, S., et al. A novel, potent, and selective 5-HT7 antagonist: (R)-3-(2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl) phenol (SB-269970). Journal of Medicinal Chemistry 43(3), 342-345 (2000).
2.Foong, J.P.P., and Bornstein, J.C. 5-HT antagonists NAN-190 and SB 269970 block α2-adrenoceptors in the guinea pig. NeuroReport 20(3), 325-330 (2009).
3.Nikiforuk, A.,Kos, T.,Fijal, K., et al. Effects of the selective 5-HT7 receptor antagonist SB-269970 and amisulpride on ketamine-induced schizophrenia-like deficits in rats. PLoS One 8(6), 1-12 (2013).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 389 |
| 分子式 | C18H28N2O3S • HCl |
| CAS号 | 261901-57-9 |
| 稳定性 | ≥ 2 years |
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