| 货号 | 14466-10mg |
| 描述 | Calpain inhibitor XII is a reversible and selective inhibitor of calpain I (μ-calpain, Ki = 19 nM), with lower affinities for calpain II (m-calpain, Ki = 120 nM) and cathepsin B (Ki = 750 nM).1 Calpain inhibitors, including this compound, have been used to study the role of calpains in diverse processes, including neutrophil chemotaxis, neuronal signaling, and cardiac response to injury.2,3,4,5 |
| 别名 | Z-L-Nva-CONH-CH2-2-Py; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Li, Z.,Ortega-Vilain, A.C.,Patil, G.S., et al. Novel peptidyl α-keto amide inhibitors of calpains and other cysteine proteases. Journal of Medicinal Chemistry 39(20), 4089-4098 (1996). 2.Khoutorsky, A. and Spira, M.E. Calpain inhibitors alter the excitable membrane properties of cultured aplysia neurons. Journal of Neurophysiology 100(5), 2784-2793 (2008). 3.Lokuta, M.A.,Nuzzi, P.A. and Huttenlocher, A. Calpain regulates neutrophil chemotaxis. Proceedings of the National Academy of Sciences of the United States of America 100(7), 4006-4011 (2003). 4.Puskarjov, M.,Ahmad, F.,Kaila, K., et al. Activity-dependent cleavage of the K-Cl cotransporter KCC2 mediated by calcium-activated protease calpain. Journal of Neuroscience 32(33), 11356-11364 (2012). 5.Cai, W.F.,Pritchard, T.,Florea, S., et al. Ablation of junctin or triadin is associated with increased cardiac injury following ischaemia/reperfusion. Cardiovascular Research 94(2), 333-341 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥90% |
| 计算分子量 | 482.6 |
| 分子式 | C26H34N4O5 |
| CAS号 | 181769-57-3 |
| 稳定性 | ≥ 2 years |
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