Bisindolylmaleimide I
货号：
13298-50mg 基本售价：
7728.0 元 规格：
50 mg
产品信息
概述| 货号 | 13298-50mg |
| 描述 | Bisindolylmaleimide I (BIM I) is a highly selective, cell-permeable, and reversible protein kinase C (PKC) inhibitor (Ki = 14 nM) that is structurally similar to the poorly selective PKC inhibitor staurosporine.1 It acts as a competitive inhibitor for the ATP binding site of PKC and shows high selectivity for PKCα-, β1-, β2-, γ-, δ-, and ε-isozymes.1 BIM I directly inhibits GSK3 in primary adipocyte lysates (IC50 = 360 nM) and in GSK3β immunoprecipitates derived from rat epididymal adipocytes (IC50 = 170 nM).2 This compound also competitively antagonizes the 5-HT3 receptor with a Ki value of 61 nM.3 |
| 别名 | BIM I;GF 109203X;Gö 6850; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Toullec, D.,Pianetti, P.,Coste, H., et al. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. The Journal of Biological Chemisty 266(24), 15771-15781 (1991).
2.Hers, I.,Tavaré, J.M., and Denton, R.M. The protein kinase C inhibitors bisindolylmaleimide I (GF 109203x) and IX (Ro 31-8220) are potent inhibitors of glycogen synthase kinase-3 activity. FEBS Letters 460, 433-436 (1999).
3.Coultrap, S.J.,Sun, H.,Tenner, T.E., et al. Competitive antagonism of the mouse 5-hydroxytryptamine receptor by bisindolylmaleimide I, a "selective" protein kinase C inhibitor. Journal of Pharmacology and Experimental Therapeutics 290(1), 76-82 (1999).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 412.5 |
| 分子式 | C25H24N4O2 |
| CAS号 | 133052-90-1 |
| 稳定性 | ≥ 2 years |
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