| 货号 | 16099-50mg |
| 描述 | Angiotensin II is a peptide hormone that regulates blood pressure and fluid balance, contributing to hypertension, atherosclerosis, left ventricular hypertrophy, myocardial infarction, and heart failure. It binds with high affinity to two distinct receptors: AT1R (angiotensin type 1 receptor) and AT2R (angiotensin type 2 receptor). AT1R activation facilitates the ‘classical’ effects, including vasoconstriction, cellular growth, and proliferation, whereas AT2R activation offsets AT1R-mediated actions, promoting vasodilatation, apoptosis, and anti-growth effects.1 PD 123319 is a selective, nonpeptide AT2R antagonist (IC50 = 5.6 nM vs. 100 nM for AT1R).1,2 It has been used to selectively examine the specific roles for AT1R and AT2R in hypertensive and other vascular research-related models.3,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Bosnyak, S.,Jones, E.S.,Christopoulos, A., et al. Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors. Clin. Sci. (Lond) 121(7), 297-303 (2011). 2.Wexler, R.R.,Greenlee, W.J.,Irvin, J.D., et al. Nonpeptide angiotensin II receptor antagonists: The next generation in antihypertensive therapy. Journal of Medicinal Chemistry 39(3), 625-656 (2014). 3.Makino, N.,Sugano, M.,Otsuka, S., et al. Molecular mechanism of angiotensin II type I and type II receptors in cardiac hypertrophy of spontaneously hypertensive rats. Hypertension 30(4), 796-802 (1997). 4.Daugherty, A.,Rateri, D.L.,Howatt, D.A., et al. PD123319 augments angiotensin II-induced abdominal aortic aneurysms through an AT2 receptor-independent mechanism. PLoS One 8(4), e61849 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 736.7 |
| 分子式 | C31H32N4O3 • 2CF3COOH |
| CAS号 | 136676-91-0 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |