| 货号 | 9002107-10mg |
| 描述 | Trimethoprim (Item No. 16473) is an antibiotic that inhibits dihydrofolate reductase (DHFR) and shows selectivity for bacterial DHFR over mammalian DHFR (IC50s = 5 and 30,000 nM, respectively).1,2 Commonly used in combination with sulfamethoxazole to minimize acquired resistance, trimethoprim has long been used against urinary tract infections.3 Trimethoprim-PEG-amine is a conjugated form of trimethoprim linked with polyethylene glycol (PEG) amine. The addition of PEG to drugs can provide greater solubility, longer duration of exposure, and the potential to overcome resistance associated with the drug.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Lam, T.,Hilgers, M.T.,Cunningham, M.L., et al. Structure-based design of new dihydrofolate reductase antibacterial agents: 7-(Benzimidazol-1-yl)-2,4-diaminoquinazolines. Journal of Medicinal Chemistry 57(3), 651-668 (2014). 2.Schweitzer, B.I.,Dicker, A.P., and Bertino, J.R. Dihydrofolate reductase as a therapeutic target. The FASEB Journal 4(8), 2441-2452 (1990). 3.Brodgen, R.N.,Carmine, A.A.,Heel, R.C., et al. Trimethoprim: A review of its antibacterial activity, pharmacokinetics and therapeutic use in urinary tract infections. Drugs 23(6), 405-430 (1982). 4.Zamboni, W.C. Concept and clinical evaluation of carrier-mediated anticancer agents. Oncologist 13(3), 248-260 (2008). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 850.6 |
| 分子式 | C23H36N6O7 • 3CF3COOH |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |