| 货号 | 20937-10g |
| 描述 | Proxyphylline is a methylxanthine derivative that has bronchodilatory actions.1 It has also been reported to have vasodilatory and cardiac stimulatory effects.2 Proxyphylline selectively antagonizes A1 adenosine receptors (Ki = 82 nM for bovine brain) versusA2 adenosine receptors (Ki = 850 µM for platelets).3 Proxyphylline has been mixed with Melilotus extract to generate a theo-esberiven product, which can have cardiovascular and anti-allodynia effects in mammals.2,4 |
| 别名 | NSC 163343; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Rasmussen, F.V.,Waldorff, S. and Madsen, L. Pharmacokinetics and bronchodilatory effect of proxyphylline and theophylline. Eur. J. Respir. Dis. 65(1), 20-27 (1984). 2.Takeda, K.,Katano, Y.,Nakagawa, Y., et al. Effects of aminophylline, proxyphylline and a proxyphylline-Melilotus extract-rutin mixture (theoesberiven) on the heart and the coronary circulation. Jpn. J. Pharmacol. 27(5), 709-720 (1977). 3.Schwabe, U.,Ukena, D. and Lohse, M.J. Xanthine derivatives as antagonists at A1 and A2 adenosine receptors. Naunyn-Schmiedebergs Arch.Pharmacol. 330, 212-221 (1985). 4.Bang, S.,Kim, Y.S. and Jeong, S.R. Anti-allodynic effect of theoesberiven F in a vincristine-induced neuropathy model. Exp. Ther. Med. 12(2), 799-803 (2016). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 238.2 |
| 分子式 | C10H14N4O3 |
| CAS号 | 603-00-9 |
| 稳定性 | ≥ 2 years |
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