| 货号 | 17871-10mg |
| 描述 | Clopidogrel (Item No. 13657) is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC50 = 100 nM).1,2 Clopidogrel inhibits ADP-induced platelet aggregation ex vivo and functions as a prodrug whereupon biotransformation to its active thiol metabolite via CYP2C19 in the liver enables its anti-aggregating activity.3 An estimated 15% of administered clopidogrel is metabolized by CYP2C19 to the thiol metabolite.4 Clopidogrel carboxylic acid is a major inactive metabolite of clopidogrel. Most (85%) of circulating clopidogrel is hydrolyzed by esterases to this carboxylic acid form.4 This inactive metabolite can be used as a reference standard for quantitative analysis of clopidogrel metabolism.5 |
| 别名 | SR26334; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Savi, P.,Labouret, C.,Delesque, N., et al. P2Y12, a new platelet ADP receptor, target of clopidogrel. Biochemical and Biophysical Research Communications 283, 379-383 (2001). 2.von Kügelgen, I. Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. Pharmacology & Therapeutics 110, 415-432 (2006). 3.Quinn, M.J., and Fitzgerald, D.J. Ticlopidine and clopidogrel. Circulation Journal 100, 1667-1672 (1999). 4.Brvar, N.,Lachance, S.,Lévesque, A., et al. Comparative bioavailability of two oral formulations of clopidogrel: Determination of clopidogrel and its carboxylic acid metabolite (SR26334) under fasting and fed conditions in healthy subjects. Acta Pharm. 64, 45-62 (2014). 5.Simeone, J.L.,Rainville, P.D., and Plumb, R.S. A high sensitivity UPLC/MS/MS method for the analysis of clopidogrel and clopidogrel carboxylic acid metabolite in human K2EDTA plasma. 1-6 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 344.3 |
| 分子式 | C15H14ClNO2S • HCl |
| CAS号 | 144750-42-5 |
| 稳定性 | ≥ 2 years |
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