Skepinone-L
货号：
16974-10mg 基本售价：
7644.0 元 规格：
10 mg
产品信息
概述| 货号 | 16974-10mg |
| 描述 | Skepinone-L is an ATP-competitive inhibitor of p38 MAPK isoform p38α (IC50s = 5 nM) and p38β (97% inhibition at 1 µM).1,2 It has little effect on a range of other kinases, including p38γ and p38δ. Skepinone-L dose-dependently blocks the phosphorylation of heat shock protein 27 (HSP27), a p38 MAPK substrate, in response to stimulation with anisomycin (Item No. 11308) in HeLa cells (IC50 = 25 nM) or TNF-α in THP-1 cells.1,2 At 1 µM, it prevents phosphorylation of cytosolic phospholipase A2 in platelets in response to collagen-related peptide or thrombin (Item No. 13188), blunting platelet secretion and aggregation.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Suzuki, O.,Katsumata, Y., and Oya, M. Oxidation of β-phenylethylamine by both types of monoamine oxidase: Examination of enzymes in brain and liver mitochondria of eight species. Journal of Neurochemistry 36(3), 1298-1301 (1981).
2.Yang, H.Y., and Neff, N.H. β-Phenylethylamine: A specific substrate for type B monoamine oxidase of brain. Journal of Pharmacology and Experimental Therapeutics 187(2), 365-371 (1973).
3.Kim, D.,Kowalchick, J.E.,Edmondson, S.D., et al. Triazolopiperazine-amides as dipeptidyl peptidase IV inhibitors: Close analogs of JANUVIAT (sitagliptin phosphate). Bioorganic & Medicinal Chemistry Letters 17(12), 3373-3377 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 425.4 |
| 分子式 | C24H21F2NO4 |
| CAS号 | 1221485-83-1 |
| 稳定性 | ≥ 2 years |
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