BIBW 2992
货号：
11492-50mg 基本售价：
7644.0 元 规格：
50 mg
产品信息
概述| 货号 | 11492-50mg |
| 描述 | BIBW 2992 is an anilino-quinazoline that irreversibly inhibits EGFR and HER2 kinase activity in cell-free in vitro kinase assays (IC50s = 0.5 and 14 nM, respectively).1 It demonstrates potent activity against mutant forms of EGFR and HER2, including erlotinib-resistant isoforms (IC50 = 10 nM), and displays weak activity when evaluated against a panel of 52 additional tyrosine and serine/threonine kinases.1 BIBW 2992 suppresses transformation in isogenic cell-based assays, inhibits survival of cancer cell lines, and at 20 mg/kg, induces tumor regression in xenograft and transgenic lung cancer models.1,2 |
| 别名 | Afatinib;Tomtovok™; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Li, D.,Ambrogio, L.,Shimamura, T., et al. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene 27(34), 4702-4711 (2008).
2.Youli, P.,Xu, Y.,Feng, S., et al. SKLB1206, a novel orally available multi-kinase inhibitor targeting EGFR activating and T790M mutants, ErbB2, ErbB4 and VEGFR2, displays potent antitumor activity both in vitro and in vivo. Molecular Cancer Therapeutics 11(4), 952-962 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 485.9 |
| 分子式 | C24H25ClFN5O3 |
| CAS号 | 439081-18-2 |
| 稳定性 | ≥ 2 years |
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