| 货号 | 17166-500mg |
| 描述 | Sedanolide is a natural phthalide first isolated from seed oil of the Umbelliferae family, including celery. It induces the expression of glutathione S-transferase and reduces chemical-induced carcinogenesis in mice.1 Sedanolide inhibits cyclooxygenases-1 and -2 at 250 pg/ml and blocks topoisomerase-I and-II activity at 100 µg/ml.2 It is mosquitocidal, nematicidal, and antifungal but shows no cytotoxicity against normal mammalian cells.3,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Zheng, C.Q.,Kenney, P.M.,Zhang, J., et al. Chemoprevention of benzo[a]pyrene-induced forestomach cancer in mice by natural phthalides from celery seed oil. Nutrition and Cancer 19, 77-86 (1993). 2.Momin, R.A. and Nair, M.G. Antioxidant, cyclooxygenase and topoisomerase inhibitory compounds from Apium graveolens Linn. seeds. Phytomedicine 9, 312-318 (2002). 3.Momin, R.A. and Nair, M.G. Mosquitocidal, nematicidal, and antifungal compounds from Apium graveolens L. seeds. Journal of Agricultural and Food Chemistry 49(1), 142-145 (2001). 4.Woods, J.A.,Jewell, C. and OBrien, N.M. Sedanolide, a natural phthalide from celery seed oil: Effect on hydrogen peroxide and tert-butyl hydroperoxide-induced toxicity in HepG2 and CaCo-2 human cell lines. In Vitr.Mol.Toxicol. 14, 233-240 (2001). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 194.3 |
| 分子式 | C12H18O2 |
| CAS号 | 6415-59-4 |
| 稳定性 | ≥ 2 years |
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