A-366
货号：
16081-50mg 基本售价：
7616.0 元 规格：
50 mg
产品信息
概述| 货号 | 16081-50mg |
| 描述 | A-366 is a potent, peptide-competitive inhibitor of the lysine methyltransferase G9a (IC50 = 3.3 nM).1 It displays greater than 1,000-fold selectivity over 21 other methyltransferases.1 A-366 significantly reduces the cellular levels of dimethylation on histone 3 at lysine 9 (H3K9Me2) in PC3 cells without reducing total histone 3, H3K27Me3, or H3K36Me2.1 It also blocks the interaction of the methyl lysine reader protein Spindlin1 with H3K4me3 by binding with a Spindlin1 Tudor domain (Kd = 111 nM).2 See the Structural Genomics Consortium (SGC) website for more information. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sweis, R.F.,Pliushchev, M.,Brown, P.J., et al. Discovery and development of potent and selective inhibitors of histone methyltransferase G9a. ACS Med.Chem.Lett. 5(2), 205-209 (2014).
2.Wagner, T.,Greschik, H.,Burgahn, T., et al. Identification of a small-molecule ligand of the epigenetic reader protein Spindlin1 via a versatile screening platform. Nucleic Acids Research (2016).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 329.4 |
| 分子式 | C19H27N3O2 |
| CAS号 | 1527503-11-2 |
| 稳定性 | ≥ 2 years |
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