UNC2025
货号：
16613-50mg 基本售价：
7616.0 元 规格：
50 mg
产品信息
概述| 货号 | 16613-50mg |
| 描述 | UNC2025 is a potent, orally bioavailable inhibitor of the tyrosine kinases Mer and Flt3 (IC50s = 0.74 and 0.80 nM, respectively).1 It less potently inhibits Axl and Tyro3 (IC50s = 14 and 17 nM, respectively) and a panel of related kinases.1 UNC2025 blocks colony formation of Mer- and Flt3-dependent tumor cell lines and inhibits Mer phosphorylation in bone marrow leukemia cells in vivo.1 Pharmacokinetic studies suggest that orally administered UNC2025 at 3 mg/kg will suffice to provide 90% inhibition of Mer and Flt3 at 30 min.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Zhang, W.,DeRychere, D.,Hunter, D., et al. UNC2025, a potent and orally bioavailable MER/FLT3 dual inhibitor. Journal of Medicinal Chemistry 57(16), 7031-7041 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 476.7 |
| 分子式 | C28H40N6O |
| CAS号 | 1429881-91-3 |
| 稳定性 | ≥ 2 years |
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