AMG 706
货号：
17671-50mg 基本售价：
7602.0 元 规格：
50 mg
产品信息
概述| 货号 | 17671-50mg |
| 描述 | AMG 706 is a multikinase inhibitor that predominantly targets receptor tyrosine kinases, including VEGFR1, VEGFR2, VEGFR3, c-Kit, PDGFR, and RET (IC50s = 2, 3, 6, 8, 84, and 59 nM, respectively).1 It also potently inhibits CSF1R and ZAK (IC50s = 5.6 and 8 nM, respectively), as well as several mutants of c-Kit.2 AMG 706 inhibits the proliferation of human endothelial cells induced by VEGF but not FGF.1 Oral administration of AMG 706 blocks VEGF-induced angiogenesis in the rat corneal model and induces regression of established A431 xenografts in mice.1 |
| 别名 | Motesanib; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Polverino, A.,Coxon, A.,Starnes, C., et al. AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts. Cancer Research 66(17), 8715-8721 (2006).
2.Davis, M.I.,Hunt, J.P.,Herrgard, S., et al. Comprehensive analysis of kinase inhibitor selectivity. Nat.Biotechnol. 29(11), 1046-1051 (2011).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 569.4 |
| 分子式 | C22H23N5O • 2H3PO4 |
| CAS号 | 857876-30-3 |
| 稳定性 | ≥ 2 years |
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