| 货号 | 3495/50 |
| 别名 | 9-β-D-Arabinofuranosyl-2-fluoro-9H-p |
| 供应商 | Tocris |
| 生物活性 | Purine analog that inhibits DNA synthesis. Exhibits antiproliferative activity (IC50 = 1.54 μM in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression. Inhibits cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in lymphocytes. Also displays anticancer activity against hematological malignancies in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 285.23 |
| 分子式 | C10H12FN5O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 21679-14-1 |
| 参考文献 | Menget al (2007) Antitumor activity of fludarabine against human multiple myeloma in vitroandin vivo. Eur.J.Haematol. 79 486. PMID: 17976186. Torellaet al (2007) Fludarabine prevents smooth muscle proliferation in vitro and neointimal hyperplasia in vivo through specific inhibition of STAT-1 activation. Am.J.Physiol.Heart Circ.Physiol. 292 H2935. PMID: 17293493. Bellosilloet al (1999) In vitro evaluation of fludarabine in combination with cyclophosphamide and/or mitoxantrone in B-cell chronic lymphocytic leukemia. Blood 94 2836. PMID: 10515887. Franket al (1999) Fludarabine-induced immunosuppression is associated with inhibition of STAT1 signaling. Nat.Med. 5 444. PMID: 10202937. |