| 货号 | 17245-5mg |
| 描述 | Enniatins are cyclohexadepsipeptides commonly isolated from fungi and are known to have antibiotic properties. Many act as ionophores, forming pores in cellular membranes to allow selective ion transport.1,2 Enniatin B1 is one of four major analogs of the enniatin complex (Item No. 9002040). It has been shown to induce apoptosis in several cancer lines (EC50s ≤ 10 µM) and to decrease the activation of the cell proliferation kinase, ERK (p44/p42).3 Enniatin B1 also inhibits the multi-drug resistance transporter Pdr5p from S. cerevisiae and has been used to examine drug resistance mechanisms.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Sy-Cordero, A.A.,Pearce, C.J., and Oberlies, N.H. Revisiting the enniatins: A review of their isolation, biosynthesis, structure determination and biological activities. J.Antibiot.(Tokyo) 65(11), 541-549 (2012). 2.Kamyar, M.R.,Rawnduzi, P.,Studenik, C.R., et al. Investigation of the electrophysiological properties of enniatins. Archives of Biochemistry and Biophysics 429(2), 215-223 (2004). 3.Wätjen, W.,Debbab, A.,Hohlfeld, A., et al. Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation. Mol.Nutr.Food Res. 53(4), 431-440 (2009). 4.Hiraga, K.,Yamamoto, S.,Fukuda, H., et al. Enniatin has a new function as an inhibitor of Pdr5p, one of the ABC transporters in Saccharomyces cerevisiae. Biochemical and Biophysical Research Communications 328(4), 1119-1125 (2005). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% |
| 计算分子量 | 653.9 |
| 分子式 | C34H59N3O9 |
| CAS号 | 19914-20-6 |
| 稳定性 | ≥ 2 years |
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