D-AP5
货号：
14539-100mg 基本售价：
7560.0 元 规格：
100 mg
产品信息
概述| 货号 | 14539-100mg |
| 描述 | D-AP5 is a selective N-methyl-D-aspartate (NMDA) receptor antagonist (Kd = 1.4 μM) that competitively inhibits the glutamate binding site of NMDA receptors.1 Whereas D-AP5 is the active (−)-stereoisomer, its (+)-isomer (L-AP5) demonstrates considerably less potent NMDA receptor antagonist activity.1 AP5 has been widely used to study the activity of NMDA receptors particularly in regard to researching synaptic plasticity, learning, and memory.2 |
| 别名 | D-2-Amino-5-Phosphonovaleric acid;D-APV; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Evans, R.H.,Francis, A.A.,Jones, A.W., et al. The effects of a series of ω-phosphonic α-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations. Br.J.Pharmac. 75, 65-75 (1982).
2.Morris, R.J. Synaptic Plasticity and Learning: Selective Impairment of Learning in Rats and Blockade of Long-Term Potentiation in vivo by the N-Methyl-D-Aspartate Receptor Antagonist AP5. Journal of Neuroscience 9, 3040-3057 (1989).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 197.1 |
| 分子式 | C5H12NO5P |
| CAS号 | 79055-68-8 |
| 稳定性 | ≥ 2 years |
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